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β-Amyloid

a. Amyloid beta (1-42) and fragments
b. AICD (APP intracellular domain)
c. Soluble fragments of Amyloid Precursor Proteins

 

 

1a. Amyloid beta (1-42) and Fragments

 

Amyloid-β Related Products

%Amyloid beta%

 

1b. AICD Fragments derived from Prepro-APP Pathway

Schematic diagram of APP sequential processing (not drawn in scale). EC: extracellular; TM: transmembrane; IC: intracellular. AB domain is highlighted in red. For simplicity, only one cleavage site is shown for each enzyme.

Hui Zheng and Edward H Koo, Mol Neurodegener. 2006; 1 : 5.

APP Intracellular Domain (AICD) Contributes to AD Pathology
Independently of AB

AICD (Short form of APP Intracellular Domain) (Human) / Beta-Amyloid Precursor (727-770), Catalog No.: 018-69

Long Form of APP Intracellular Domain (AICD) (Human) = Human Beta-Amyloid Precursor (712-770), Catalog No.: 018-70

 

APP Intracellular Domain (AICD) Related Products

%AICD%;%C-31%

 

1c. Other Soluble Fragments of Amyloid Precursor Proteins

Schematic of the different peptides administered to rats post-injury by Corrigan et. Al.

 

β-Amyloid Precursor Related Products

%018-65%;%018-66%;%018-67%

1a. Amyloid beta (1-42) and Fragments

Click to Expand

Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang et al. Proc Natl Acad Sci U S A. 2010 Mar 22.

Click to Expand

Pyroglutamate-AB: Role in the natural history of Alzheimer's disease.

Gunn AP, et al. Int J Biochem Cell Biol. 2010 Dec;42(12):1915-8. Epub 2010 Sep 15.

Click to Expand

Identification of low molecular weight pyroglutamate abeta oligomers in Alzheimer disease

Wirths O, et al. J Biol Chem. 2010 Dec 31;285(53):41517-24. Epub 2010 Oct 22.

Click to Expand

Anti-11[E]-pyroglutamate-modified amyloid B antibodies cross-react with other pathological AB species: Relevance for immunotherapy.

Perez-Garmendia R, et al. J Neuroimmunol. 2010 Dec 15;229(1-2):248-55. Epub 2010 Sep 22.

Amyloid-β Related Products

%Amyloid beta%

this series of peptides currently don't have any antibody staining graphs available, please inquire us to get the latest updates.

Amyloid β-Protein (1-40) (Human) ELISA Kit (EK-018-01)

Human beta-Amyloid Precursor Sequence and Derived Peptides

Please go to "Research Abstracts" section for more references


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