Adipokinetic Hormone (Heliothis
zea and Manduca sexta)
047-06
154
Adipokinetic Hormone II (Schistocera
gregaria)
047-10
155
Adipokinetic Hormone (Taa-AKH) (Tabanus
atratus)
047-08
156
Adipokinetic Hormone G (AKH-G) (Gryllus
bimaculatus)
047-11
157
Hypothetical Protein XP_294524 (190-196)-NH2
/P52/QRFP-7 (Human) (10/02/03)
GPR103/SP9155/AQ27
048-75
158
Hypothetical Protein XP_294524 (171-196)-NH2
(H)/P518/QRFP-26 (10/02/03)
GPR103/SP9155/AQ27
048-76
159
Proctolin
CG6986
026-60
160
PBAN (Hez) (07/30/03)
PBAN-R
047-60
161
Leucopyrokinin (LPK) (07/30/03)
039-10
162
Myomodullin (07/16/03)
PBAN-R
047-54
163
Diuretic Hormone (DH) (02/04/04)
DH-R/CG8422
070-24
164
Chemerin/TIG-2 (145-157) (Human) (07/20/04)
ChemR23
002-50
165
Neuropeptide S (Human) (08/20/04)
NPSR
005-89
166
Neuropeptide S (Rat) (08/20/04)
NPSR
005-88
167
Neuropeptide S (Mouse) (08/20/04)
NPSR
002-91
168
Neuromedin S (Human) (01/08/05)
FM-4/TGR-1
045-86
169
Neuromedin S (Rat) (01/08/05)
FM-4/TGR-1
045-87
170
Neuromedin S (Mouse) (01/08/05)
FM-4/TGR-1
171
Beta-Alanine (02/08/05)
TGR7
074-18
172
Adenine (02/08/05)
Adenine Receptor
074-08
173
Adenine hydrochloride (02/08/05)
Adenine Receptor
074-09
174
Obestatin (Human) (02/08/06)
GPR39
031-92
175
Obestatin (Rat) (02/08/06)
GPR39
031-90
176
Endothelin-like Peptide (06-11/06)
orphan GPCR
177
Retinol-binding protein-4 (06/11/06)
031-90
References:
Hinuma, S., et al. The quest for novel bioactive peptides
utilizing orphan seven-membrane-domain receptors. Journal of Molecular Medicine 77, 495-504 (1999)
Ames, R.S., et al. Human urotensin II is a potent vasoconstrictor
and agonist for the orphan receptor GPR14. Nature 401, 282-286 (1999)
Nothacker, H.-P. et al., Identification of the natural ligand
of an orphan G-protein-coupled receptor involved in the regulation
of vasoconstriction. Nature Cell Biology 1, 383-385 (1999)
Chambers, J. et al., Melanin-concentrating hormone is the
cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400, 261-265 (1999)
Hinuma, S. et al., Molecular cloning and functional expression
of a human thyrotropin-releasing hormone (TRH) receptor gene.
Biochemica Biophysica acta 1219, 251-259 (1994)
Fujii, R., et al. Tissue distribution of prolactin-releasing
peptide (PrRP) and its receptor. Regulatory Peptides (1999,
in press)
Lecea, L., et al. The hypocretins: hypothalamus-specific
peptides with neuroexcitatory activity. PNAS 95, 322-327
(1998)
Sakurai, T.S., et al. Orexins and orexin receptors: a family
of hypothalamic neuropeptides and G protein-couples receptors
that regulate feeding behavior. cell
92,573-585(1998)
Tatemoto K., et al. isolation and characterization of a
novel endogenous peptide ligand for the human APJ receptor.
Biochem Biophys Res Commun 251, 471-476 (1998)
Meunier, J-C., et al. Isolation and structure of the endogenous
agonist of opioid receptor-like ORL1 receptor. Nature 377,532-535(1995)
Reinscheid, R. K., et al. Orphanin FQ: A neuropeptide that
activates an opioid-like G protein -coupled receptor. Science
270,792-794(1995)
Cox, K. J.A. et al. Cloning, characterization, and expression
of a G-protein-coupled receptor from Lymnaea stagnails and
identification of a leucokinin-like peptide, FSFHSWSamide,
as its endogenous ligand. J Neurosci 17,1197-1205(1997)
Tensen, C. P., et al. The Lymnaea cardioexcitatory peptide
(LyCEP) receptor: a G-protein-coupled receptor for a novel
member of the Rfamide neuropeptide family. J Neurosci 18,9812-9821(1998)
Liu, Q., et al. Identification of urotensin II as the endogenous
ligand for the orphan G-protein-coupled receptor GPR14. Biochem
Biophys Res Commun 266,174-178(1999)
Mori, M., et al. Urotensin II is the endogenous ligand of
a G-protein-coupled orphan receptor, SENR (GPR14). Biochem Biophys Res Commun. 265, 123-129(1999).
Lembo, P. M., et al.The receptor for the orexigenic peptide
melanin-concentrating hormone is a G-protein-coupled receptor. Nat Cell Biolog. 1, 267-271(1999)
Habata, Y., et al. Apelin, the natural ligand of the orphan
receptor APJ, is abundantly secreted in the colostrum.
Biochim Biophys Acta. 1452, 25-35(1999)
Kojima, M., et al. Ghrelin is a growth-hormone-releasing
acylated peptide from stomach. Nature 402,656-660(1990)
Elshourbagy N.A., et al. Receptor for the Pain Modulatory
Neuropeptides NPFF and NPAF is an Orphan G-Protein-Coupled
Receptor. JBC (June 12, 2000)
Szekeres, P.G., et al. Neuromedin U is a potent agonist
at the orphan G protein coupled receptor FM3. JBC (May 12,
2000)
Fujii R., et al. Identification of Neuromedin U as the cognate
ligand of the orphan G protein-coupled receptor FM-3. JBC
(April 26, 2000)
Howard A. D., et al. Identification of receptors for neuromedin
U and its role in feeding. Nature 406 (6 July), 70-75 (2000)
Feighner SD, et al., Receptor for motilin identified in
the human gastrointestinal system. Science 1999 Jun 25;284(5423):2184-8.
Hinuma S., et al. New neuropeptides containing carboxy-terminal
RFamide and their receptor in mammals. Nature Cell Biology,
2, 703-708 (2000)
Lee, D.L., et al. Orphan G protein-coupled receptors in
the CNS. Cuur. Opin. Pharmacol. 1, 31-39 (2001)
Howard, A. D., et al. Orphan G-protein-coupled receptors
and natural ligand discovery. Trends Pharmacol. Sci. 22, 132-140
(2001)
Civelli, O., et al. Novel neurotransmitters as natural ligands
of orphan G-protein-coupled receptors. Trends Neurosci. 24,
230-237 (2001)
Christophe, T., et al. The synthetic Trp-Lys-Tyr-Met-Val-Met-NH2
specifically activates neutrophils through FPRL1/LXA4R and
is an agonist for the orphan monocyte-expressed chemoattactant
receptor FPRL2. JBC online (April 2, 2001)
Fujii R. et al. Identification of a neuropeptide modified
with Bromine as an endogenous ligand for GPR7. Papers In Press,
published online ahead of print July 12, 2002J. Biol. Chem,
10.1074/jbc.M205883200
Shimomura, Y., et al. Identification of neuropeptide W (NPW)
as the endogenous ligand for orphan G-protein-coupled receptors,
GPR7 and GPR8 Papers In Press, published online ahead of print
July 18, 2002. J. Biol. Chem, 10.1074/jbc.M205337200
Ohtaki T, et al. Metastasis suppressor gene KiSS-1 encodes
peptide ligand of a G-protein-coupled receptor. Nature. 2001
May 31;411(6837):613-7
Kotani M, et al. The metastasis suppressor gene KiSS-1 encodes
kisspeptins, the natural ligands of the orphan G protein-coupled
receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6
GrandPre T, Li S, Strittmatter SM. Nogo-66 receptor antagonist
peptide promotes axonal regeneration. Nature. 2002 May 30;417(6888):547-51
Liu BP, Fournier A, GrandPre T, Strittmatter SM. Myelin-associated
glycoprotein as a functional ligand for the nogo-66 receptor.
Science. 2002 Aug 16;297(5584):1190-3
Kumagai J, Hsu SY, Matsumi H, Roh JS, Fu P, Wade JD, Bathgate
RA, Hsueh AJ. J Biol Chem 2002 Aug 30;277(35):31283-6
Sudo S. et al. H3 relaxin is a specific ligand for LGR7
and activates the receptor by interacting with both the ectodomain
and the exoloop 2.
J. Biol. Chem, Feb 2003; 278: 7855 - 7862.
Staubli F, et al. Molecular identification of the insect
adipokinetic hormone receptors. Proc Natl Acad Sci U S A 2002
Mar 19;99(6):3446-51
Man-Yeon Choi M. Y., et al. Identification of a G protein-coupled
receptor for pheromone biosynthesis activating neuropeptide
from pheromone glands of the moth Helicoverpazea
.Proc. Natl. Acad. Sci. USA,
10.1073/pnas.1632485100. 2003
July 29; [epub ahead of print]
Johnson EC, et al. Identification
and characterization of a G protein-coupled receptor for the
neuropeptide proctolin in Drosophilamelanogaster Proc
Natl Acad Sci U S A 2003 May 2; [epub ahead of print]
Jiang Y, et al.Identification
and characterization of a novel RF-amide peptide ligand for
orphan G-protein coupled receptor SP9155 J
Biol Chem 2003 Apr 24; [epub ahead of print]
Fukusumi S, et al. A new peptidic ligand and its receptor
regulating adrenal function in ratsJ Biol Chem. 2003
Sep 5 [Epub ahead of print].
Boels K, Schaller HC. Identification and characterisation
of GPR100 as a novel human G-protein-coupled bradykinin receptor.Br
J Pharmacol. 2003 Oct 6 [Epub ahead of print].
Liu C, et al. Identification of relaxin-3/INSL7 as an endogenous
ligand for the orphan G-protein coupled receptor GPCR135.
J Biol Chem. 2003 Sep 30 [Epub ahead of print].
Liu C, et al. Identification of relaxin-3/INSL7 as a ligand
for GPCR142. J Biol Chem. 2003 Sep 30 [Epub ahead of print].
Kubiak TM, et al. Differential activation of "social" and
"solitary" variants of the C. elegans GPCR NPR-1 by its cognate
ligand AF9. J Biol Chem. 2003 Jun 23 [Epub ahead of
print]
Johnson EC, Bohn LM, Taghert PH. Drosophila CG8422 encodes
a functional diuretic hormone receptor.J Exp Biol.
2004 Feb 15;207(Pt 5):743-8
Medera W., et al. Characterization of human circulating
TIG2 as a ligand for the orphan receptor ChemR23. FEBS Letters
555 (2003) 495~499
Xu Y.L., et al. Neuropeptide S: A Neuropeptide Promoting
Arousal and Anxiolytic-like Effects. Neuron, Vol 43, 487-497,
19 August 2004
Mori K, et al. Identification of neuromedin S and its possible
role in the mammalian circadian oscillator system. EMBO J.
2005 Jan 06; [Epub ahead of print]
Shinohara T, et al. Identification of a G protein-coupled
receptor specifically responsive to beta-alanine. J Biol Chem.
2004 May 28;279(22):23559-64. Epub 2004 Mar 22
Bender E, et al. Characterization of an orphan G protein-coupled
receptor localized in the dorsal root ganglia reveals adenine
as a signaling molecule. Proc Natl Acad Sci U S A. 2002 Jun
25;99(13):8573-8
Zhang J. V., et al. Science, Vol 310, Issue 5750, 996-999
, 11 November 2005
Ujiie H,
et al. Identification of amino-terminal region of adiponectin
as a physiologically functional domain. J Cell Biochem.
2006 Jan 11; [Epub ahead of print]
Ma Y. X., et al. Molecular Human Reproduction, Vol. 8, No.
1, 24-31, January 2002
Rezgaoui M, et al. The neuropeptide head activator is a
high-affinity ligand for the orphan G-protein-coupled receptor
GPR37. J Cell Sci. 2006 Feb 1;119(Pt 3):542-9.
