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Our libraries are continuously updated to include all new and current peptides, receptors and references.
From thousands of peptides from our stock, we have put together various peptide family libraries for receptor and natural ligand studies:
Alzheimer Fingerprint Library*
G Protein Coupled Receptor Peptide Ligand Library*:
More than 40 families of identified or suspected G Protein Coupled Receptor Peptide Ligands as well as its related agonists and antagonists enable a "reverse pharmacology approach" for large scale screening Orphan G Protein Coupled Receptors included over five hunderd peptides which are HPLC-purified and fluorescein free. This library covers various newly identified G Protein Coupled Receptor Ligands including RFamide Related Peptides (OT7T022), Neuromedin U (NmU R-1/FM-3 and NmU R-2/FM-4), human Urotensin II (GPR14), Neuropeptide AF/FF(NPFF-1 and NPFF-2), Ghrelin(GHS-Rs), Motilin(GPR-38-A), MCH(SLC-1), Orexins and Hypocretins (HFGAN-72), Prolactin Releasing Peptide (HGR-3/GPR-10/UHR-1), Orphanin FQ (ORL-1) and Apelin(APJ).
Chop-Suey Peptides Library (Variety Pack)*
Opioid Peptides Library*
Obesity Related Peptide Library*
Gastrointestinal Peptides Library*
Brain Peptide Library (Bees)
Anti-angiogenic Peptide Library
Custom Peptide Library
 
Phoenix's Peptide Receptor Ligand Libraries, a broad
set of peptides (thousands), enables a "reverse pharmacology" approach
to identify unknown membrane receptors, G-protein-coupled receptors, ion
channels, intracellular signaling enzymes and receptors.Feighner et al. (1),
successfully identified a human motilin receptor using the Phoenix
Gastrointestinal Peptide Library and HEK293 cells in which a human
motilin receptor was coexpressed with aequorin, a bioluminescent calcium
sensitive reporter protein. A similar approach was taken by Chambers et al. (2),
to identify an orphan G-protein coupled receptor as a human MCH
receptor, using over 700 naturally occurring and putative
neuropeptide's. Recently, neuromedin U has been identified as a natural
ligand for two orphan G protein coupled receptors, FM-3 and FM-4.
Howard, A.D. et al. Nature 406, 70-75 (July 6, 2000)
References:
1. Feighner, S.D. et al., Science 284, 2184-2188 (1999)
2. Chambers, J. et al., Nature 400, 261-265 (1999)
3. Howard, A.D. et al.Identification of receptors for neuromedin U and its role in feeding. Nature 406, 70-75 (July 6, 2000).
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